Principal Investigator/Project Lead: Project 1
Stanford University, Stanford, California
Dr. Südhof is Professor of Molecular & Cellular Physiology at Stanford University School of Medicine. When Dr. Südhof started his laboratory at UT Southwestern in 1986, he decided to switch from cholesterol metabolism to neuroscience, and to pursue a molecular characterization of synaptic transmission. His work initially focused on the mechanism of neurotransmitter release which is the first step in synaptic transmission, and whose molecular basis was completely unknown in 1986. Later on, Dr. Südhof’s work increasingly turned to the analysis of synapse formation and specification, processes that mediate the initial assembly of synapses, regulate their maintenance and elimination, and determine their properties. In 2008, Dr. Südhof moved to Stanford University School of Medicine and became the Avram Goldstein Professor in the School of Medicine at Stanford University. In addition, Dr. Südhof has been an Investigator of the Howard Hughes Medical Institute since 1986. In 2013, he won the Nobel Prize in Physiology or Medicine in the field of cell physiology and neurophysiology.